Epidemiological and genomic characteristics of Acinetobacter baumannii from different infection sites using comparative genomics

Abstract Background Acinetobacter baumannii is a common nosocomial pathogen that poses huge threat to global health. Owing the severity of A. infections, it became necessary investigate epidemiological characteristics in Chinese hospitals and find reasons for high antibiotic resistance rate mortality. This study aimed epidemiologic genetic isolated from patients with hospital acquired pneumonia (HAP), bloodstream infection (BSI) urinary tract (UTI) China uncover potential mechanisms multi-drug virulence isolates. Results All isolates were classified into two primary clades core gene-based phylogenetic relationship. Clonal complex 208 (CC208) mainly consisted ST195 (32 %) ST208 (24.6 %). CC208 non-CC208 had carbapenem rates 96.2 9.1 %, respectively. Core genes enriched ‘Amino acid transport metabolism’, ‘Translation’, ‘Energy production conversion’, ‘Transcription’, ‘Inorganic ion metabolism’ ‘Cell wall/membrane/envelope synthesis’. Most possessed factors related polysaccharide biosynthesis, capsular synthesis motility. Eleven belong ST369 or ST191 (oxford scheme) all factor cap8E higher positive UTI (35.3 than BSI (18.9 HAP (12.9 ABGRI1 islands responsible streptomycin, tetracycline sulfonate resistance. The bla OXA?23 gene was most probable cause resistance, although OXA?66 nonsynonymous SNPs (F82L, I129L) not. Conclusions genomically variable has range infectious diseases. There proportion three sites (HAP, UTI), which can be attributed gene. predominant clone -carrying should monitored. Virulence involving bacteria motility biosynthesis are widespread clinical strains deserve our attention.